A Chimeric Sperm Peptide Induces Antibodies and Strain-Specific Reversible Infertility in Mice1
نویسندگان
چکیده
منابع مشابه
Human sperm-specific peptide vaccine that causes long-term reversible contraception.
A novel dodecamer peptide sequence, YLP(12), was identified on human sperm that is involved in oocyte binding. We investigated its immunocontraceptive effects in a murine model. A vaccine was prepared by conjugating the synthetic YLP(12) peptide with the binding subunit of recombinant cholera toxin. Vaccination of female mice by i.m. or intranasal routes without any additional adjuvant induced ...
متن کاملSperm counts and sperm sex ratio in male infertility patients.
In recent years, investigators have noted a trend toward a declining proportion of male births in many industrialized nations. While men bear the sex-determining chromosome, the role of the female partner as it pertains to fertilization or miscarriage may also alter the gender ratio. We attempted to determine a man's secondary sex ratio (F1 generation) by directly examining the sex chromosomes ...
متن کاملAcrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities.
OBJECTIVE To detect the presence of antibodies to the proacrosin/acrosin system and to evaluate their effect on the sperm acrosomal protein activities in women consulting for infertility. DESIGN Retrospective study. SETTING Basic research laboratory. PATIENT(S) Recombinant proteins derived from human proacrosin (Rec-40, Rec-30, Rec-20, Rec-10) and recombinant human zona pellucida (ZP) gly...
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Background: Pseudomonas aeruginosa, an opportunistic pathogen, is a common cause of healthcare-associated infections in immunocompromised individuals. The rapid emergence of multidrug-resistant strains has made P. aeruginosa infections progressively difficult to treat. In this study we evaluated the effect of a chimeric protein containing a P. aeruginosa PilQ fragment and the PilA disulfide loo...
متن کاملAntimicrobial peptide Brevinin-2R induces the secretion of a pro-inflammatory cytokine in HepG2 cells
Introduction: Antimicrobial peptides as the body's defense strategy play an important role in resistance against infection of microorganism. These peptides are able to modulate the immune and inflammatory processes through the production of defensive molecules. Therefore, the modulatory effects of Brevinin-2R, an antimicrobial peptide extracted from the skin of the frog (Rana ridibunda), was ev...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1998
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod59.3.527